全文获取类型
收费全文 | 9945篇 |
免费 | 986篇 |
国内免费 | 171篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 139篇 |
妇产科学 | 61篇 |
基础医学 | 719篇 |
口腔科学 | 156篇 |
临床医学 | 756篇 |
内科学 | 2113篇 |
皮肤病学 | 157篇 |
神经病学 | 903篇 |
特种医学 | 182篇 |
外国民族医学 | 1篇 |
外科学 | 286篇 |
综合类 | 621篇 |
现状与发展 | 2篇 |
预防医学 | 1004篇 |
眼科学 | 48篇 |
药学 | 3087篇 |
1篇 | |
中国医学 | 404篇 |
肿瘤学 | 435篇 |
出版年
2023年 | 241篇 |
2022年 | 194篇 |
2021年 | 451篇 |
2020年 | 306篇 |
2019年 | 343篇 |
2018年 | 451篇 |
2017年 | 473篇 |
2016年 | 435篇 |
2015年 | 378篇 |
2014年 | 523篇 |
2013年 | 1489篇 |
2012年 | 419篇 |
2011年 | 453篇 |
2010年 | 382篇 |
2009年 | 379篇 |
2008年 | 401篇 |
2007年 | 386篇 |
2006年 | 347篇 |
2005年 | 313篇 |
2004年 | 297篇 |
2003年 | 277篇 |
2002年 | 220篇 |
2001年 | 180篇 |
2000年 | 184篇 |
1999年 | 122篇 |
1998年 | 120篇 |
1997年 | 111篇 |
1996年 | 103篇 |
1995年 | 109篇 |
1994年 | 92篇 |
1993年 | 89篇 |
1992年 | 70篇 |
1991年 | 87篇 |
1990年 | 68篇 |
1989年 | 55篇 |
1988年 | 67篇 |
1987年 | 55篇 |
1986年 | 42篇 |
1985年 | 76篇 |
1984年 | 65篇 |
1983年 | 34篇 |
1982年 | 43篇 |
1981年 | 36篇 |
1980年 | 37篇 |
1979年 | 24篇 |
1978年 | 16篇 |
1977年 | 18篇 |
1976年 | 8篇 |
1975年 | 8篇 |
1974年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 250 毫秒
31.
32.
AbstractThe leading cause of death of adolescents in developed countries is injury. Alcohol is a major contributor to adolescent injury. Most of the injury deaths in youth are caused by traffic crashes. Driving under the influence (DUI) and riding with a driver who is under the influence (RUI) of alcohol increase the risk of road crash. The focus of this study is how adolescents’ risk of DUI and RUI differ in relation to their experience of parental control and peer pressure to substance use, other risky behaviours and leisure time activities. The analyses are based on data from the European School Survey Project on Alcohol and Other Drugs collected from 15- to 16-year-old Finnish adolescents in 2015 (n?=?4049, response rate 88.7%). The study shows that problems tend to entangle in some adolescent groups in which DUI and RUI are also more common. Adolescents with higher probability of using various substances, of starting alcohol use at young age, of experiencing weak parental control, and high peer pressure are at higher risk of DUI and RUI. The results indicate that professionals and authorities handling underage DUI and RUI ought to consider adolescents’ situation as a whole. 相似文献
33.
A. Glahn P. J. Proskynitopoulos S. Bleich T. Hillemacher 《Expert opinion on pharmacotherapy》2020,21(9):1083-1092
ABSTRACT
Introduction
Alcohol withdrawal syndrome is a common and life-threatening condition in patients suffering from alcohol use disorder. Treatment of this syndrome is challenging, especially in patients that are critically ill, either because of withdrawal symptoms or underlying conditions. For the treatment, several pharmacological agents exist, such as benzodiazepines, barbiturates, or dexmedetomidine. Nonetheless, as alcohol withdrawal syndromes can occur in every clinical setting, it is necessary to provide a guideline for clinicians confronted with this syndrome in varying clinical contexts. 相似文献34.
35.
Liping Lin Megumi Suda Chenlan Xu Yuehan Zhang Yukie Yanagiba Jisheng Nie Tamie Nakajima Zuquan Weng Rui-Sheng Wang 《Journal of applied toxicology : JAT》2020,40(7):979-990
Owing to the use of ethyl tert-butyl ether (ETBE) as a fuel additive, the possible adverse effects of ETBE exposure have become a public concern. Our previous study showed that ETBE-induced toxicity in aldehyde dehydrogenase 2 (Aldh2) gene knockout (KO) mice was caused by its primary metabolite acetaldehyde, which was toxic. However, it is unclear whether tert-butyl alcohol (TBA), another main metabolite of ETBE, plays a role in ETBE-induced toxicity. To investigate this relationship, we analyzed the changes of TBA concentrations in tissues after ETBE exposure, and then evaluated the toxicity after direct TBA treatment in both KO and wild-type (WT) mice. An exposure to 500 ppm ETBE via inhalation resulted in the formation of its three metabolites, TBA, 2-methyl-1,2-propanediol and ethanol, whose concentrations in the liver, brain, fat and testis of male KO mice were significantly higher than the corresponding concentrations observed in male WT mice. Direct treatment to TBA (20 mg/mL of drinking water) caused significant changes in relative organ weights and histopathology, and increased levels of genetic damages in both types of mice. These toxic effects were also seen in KO mice exposed to a lower concentration of TBA (5 mg/mL), which was associated with increased oxidative stress in serum (reduced glutathione and reduced glutathione/oxidized glutathione ratio decreased). Our findings indicate that ALDH2 is involved in the metabolism of ETBE and TBA, and ALDH2 deficiency could greatly increase the sensitivity to TBA-induced toxicity. 相似文献
36.
37.
38.
Adrian Wong Pamela L. Smithburger 《The American journal of drug and alcohol abuse》2015,41(5):382-391
Background: The primary management of alcohol withdrawal involves the administration of a γ-aminobutyric acid agonist, such as benzodiazepines, for management of symptoms and to prevent further progression to seizure or delirium tremens. Despite escalating doses of benzodiazepines, published literature indicates that some patient’s alcohol withdrawal syndrome symptoms do not respond, and that the use of adjunctive agents may be beneficial in these patients. Dexmedetomidine, an α2-agonist, serves as a potential adjunctive agent through management of associated autonomic symptoms. Understanding of recent literature evaluating its use is necessary for appropriate selection. Objective: To review available literature supporting the use of adjunctive dexmedetomidine for management of severe alcohol withdrawal syndrome. Methods: A total of 13 published articles evaluating the efficacy and safety of dexmedetomidine as an adjunctive agent for the treatment of alcohol withdrawal in adult patients were identified from a MEDLINE search using the key words alcohol withdrawal, delirium tremens and dexmedetomidine. Results: Evaluation of the literature indicates that dexmedetomidine is associated with a decrease in short-term benzodiazepine requirements after initiation, and improvement in hemodynamic parameters in relation to the adrenergic drive present in alcohol withdrawal. Conclusion: The use of dexmedetomidine in the management of severe alcohol withdrawal should be considered as an adjunctive agent. Dexmedetomidine appears to be well tolerated, with an expected decrease in blood pressure and heart rate. Seizures have occurred in patients with alcohol withdrawal despite the use of dexmedetomidine, with and without benzodiazepines, due to lack of γ-aminobutyric acid agonist administration. 相似文献
39.
A longitudinal study of the association of adolescent polydrug use,alcohol use and high school non‐completion 下载免费PDF全文
40.
《The Journal for Nurse Practitioners》2019,15(9):627-630
Over 50 years ago, alcohol use disorder (AUD) was recognized as a treatable medical disorder negatively affecting millions of adults, yet pharmacologic management is underused. Most patients seeking AUD treatment are referred to an outpatient program or a peer support group. Relapse is common because frequently medications to treat AUD are recommended yet not prescribed for routine use concurrently with support programs. Therefore, comprehensive treatment of AUD must include pharmacologic management to prevent a relapse to alcohol use. The purpose of this article is to present evidence-based information for nurse practitioners’ pharmacologic management of AUD. 相似文献